Ibuproxam

Ibuproxam
Clinical data
ATC code
Identifiers
IUPAC name
  • N-Hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.053.331
Chemical and physical data
FormulaC13H19NO2
Molar mass221.300 g·mol−1
3D model (JSmol)
Melting point119–121 °C (246–250 °F)
SMILES
  • O=C(NO)C(c1ccc(cc1)CC(C)C)C
InChI
  • InChI=1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,16H,8H2,1-3H3,(H,14,15) N
  • Key:BYPIURIATSUHDW-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

Ibuproxam is a nonsteroidal anti-inflammatory drug (NSAID).It is the hydroxamic acid of ibuprofen to which it is hydrolyzed in the blood. It was found, that ibuproxam is considerably less damaging to the gastrointestinal tract than is ibuprofen. The analgesic and the antipyretic activities are consistent.[1]

References

  1. ^ Orzalesi G, Selleri R, Caldini O, Volpato I, Innocenti F, Colome J, Sacristan A, Varez G (1977). "Ibuproxam and ibuprofen. A pharmacological comparison". Arzneimittel-Forschung. 27 (5): 1006–12. PMID 577862.



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