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| Type I | | ALK1 (ACVRL1) |
- Agonists: Activin (A, B, AB)
- Avotermin
- BMP (10)
- Cetermin
- GDF (2 (BMP9))
- TGFβ (1, 2, 3)
- Kinase inhibitors: K-02288
- ML-347 (LDN-193719, VU0469381)
- Other inhibitors: Disitertide
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| ALK2 (ACVR1A) |
- Agonists: Activin (A, B, AB)
- AMH (MIS)
- Avotermin
- BMP (5, 6, 7, 8A, 8B)
- Eptotermin alfa
- TGFβ (1, 2, 3)
- Kinase inhibitors: DMH-1
- DMH-2
- Dorsomorphin (BML-275)
- K-02288
- ML-347 (LDN-193719, VU0469381)
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|---|
| ALK3 (BMPR1A) |
- Agonists: AMH (MIS)
- BMP (2, 4, 5, 6, 7, 8A, 8B)
- Dibotermin alfa
- Eptotermin alfa
- Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
|
|---|
| ALK4 (ACVR1B) |
- Agonists: Activin (A, B, AB)
- GDF (1, 3, 11 (BMP11))
- Myostatin (GDF8)
- Nodal
- Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
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|---|
| ALK5 (TGFβR1) |
- Agonists: Avotermin
- GDF (10 (BMP3B), 11 (BMP11))
- TGFβ (1, 2, 3)
|
|---|
| ALK6 (BMPR1B) |
- Agonists: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
- GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15)
- Radotermin
- Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
|
|---|
| ALK7 (ACVR1C) |
- Agonists: GDF (1, 3, 11 (BMP11))
- Nodal
- Antagonists: Lefty (1, 2)
- Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
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| Type II | | TGFβR2 |
- Agonists: Avotermin
- GDF (10 (BMP3B))
- TGFβ (1, 2, 3)
- Kinase inhibitors: DMH-2
- LY-364947
|
|---|
| BMPR2 |
- Agonists: BMP (2, 4, 6, 7, 10)
- Dibotermin alfa
- Eptotermin alfa
- GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Radotermin
|
|---|
| ACVR2A (ACVR2) |
- Agonists: Activin (A, B, AB)
- BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
- GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15)
- Myostatin (GDF8)
- Nodal
- Radotermin
|
|---|
| ACVR2B |
- Agonists: Activin (A, B, AB)
- BMP (2, 4, 6, 7)
- Dibotermin alfa
- Eptotermin alfa
- GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Myostatin (GDF8)
- Nodal
- Osteogenin (BMP3, BMP3A)
- Radotermin
- Decoy receptors: Ramatercept
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|---|
| AMHR2 (AMHR) | |
|---|
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| Type III | |
|---|
| Unsorted |
- Endogenous antagonists/inhibitors: BAMBI
- Cerberus (CER1)
- Chordin
- DAN (PARN)
- Decorin
- Follistatin
- Gremlin (Drm)
- LTBP1
- Noggin
- TGIF
- Thrombospondin 1 (THBS1)
- Tomoregulin 1
- Antibodies: Stamulumab (against myostatin)
- TRC105 (against endoglin)
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