Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte.[1] They are protein mediators typically produced by T cells to direct the immune system response by signaling between its cells. Lymphokines have many roles, including the attraction of other immune cells, including macrophages and other lymphocytes, to an infected site and their subsequent activation to prepare them to mount an immune response. Circulating lymphocytes can detect a very small concentration of lymphokine and then move up the concentration gradient towards where the immune response is required. Lymphokines aid B cells to produce antibodies.
Important lymphokines secreted by the T helper cell include:[2]
References
- ^ Julius M. Cruse; Robert Edwin Lewis (20 April 2009). Illustrated dictionary of immunology. CRC Press. pp. 208–. ISBN 978-0-8493-7987-1. Retrieved 24 April 2011.
- ^ Guyton, AC; Hall, JE. (2006) Medical Physiology, Elsevier Saunders. 11th edition, pp.447.
External links
- Lymphokines at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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| By family | | Chemokine | | CCL |
- CCL1
- CCL2/MCP1
- CCL3/MIP1α
- CCL4/MIP1β
- CCL5/RANTES
- CCL6
- CCL7
- CCL8
- CCL9
- CCL11
- CCL12
- CCL13
- CCL14
- CCL15
- CCL16
- CCL17
- CCL18/PARC/DCCK1/AMAC1/MIP4
- CCL19
- CCL20
- CCL21
- CCL22
- CCL23
- CCL24
- CCL25
- CCL26
- CCL27
- CCL28
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| CXCL |
- CXCL1/KC
- CXCL2
- CXCL3
- CXCL4
- CXCL5
- CXCL6
- CXCL7
- CXCL8/IL8
- CXCL9
- CXCL10
- CXCL11
- CXCL12
- CXCL13
- CXCL14
- CXCL15
- CXCL16
- CXCL17
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| CX3CL | |
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| XCL | |
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| TNF |
- TNFA
- Lymphotoxin
- TNFSF4
- TNFSF5/CD40LG
- TNFSF6
- TNFSF7
- TNFSF8
- TNFSF9
- TNFSF10
- TNFSF11
- TNFSF13
- TNFSF13B
- EDA
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| Interleukin | Type I (grouped by receptor subunit) | |
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| Type II | | IL10 family | |
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| Interferon | | I |
- IFNA1
- IFNA2
- IFNA4
- IFNA5
- IFNA6
- IFNA7
- IFNA8
- IFNA10
- IFNA13
- IFNA14
- IFNA16
- IFNA17
- IFNA21
- IFNB1
- IFNK
- IFNW1
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| II | |
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| Ig superfamily |
- IL1 family: IL1A/IL1F1
- IL1B/IL1F2
- 1Ra/IL1F3
- IL1F5
- IL1F6
- IL1F7
- IL1F8
- IL1F9
- IL1F10
- 33/IL1F11
- 18/IL1G
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| IL17 family | |
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| Other | |
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By function/ cell | |
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| Chemokine | |
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| CSF | | Erythropoietin | |
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| G-CSF (CSF3) | |
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| GM-CSF (CSF2) | |
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| M-CSF (CSF1) |
- Kinase inhibitors: Agerafenib
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| SCF (c-Kit) | |
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| Thrombopoietin | |
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| Interferon | | IFNAR (α/β, I) |
- Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
- Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
- Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
- Decoy receptors: Bifarcept
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| IFNGR (γ, II) | |
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| IFNLR (λ, III) |
- See IL-28R (IFNLR) here instead.
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| Interleukin | |
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| TGFβ | |
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| TNF | |
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| Others | |
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Authority control databases |
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| International | |
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| National | |
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| Other | |
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