The lysophosphatidic acid receptors (LPARs) are a group of G protein-coupled receptors for lysophosphatidic acid (LPA) that include:
- Lysophosphatidic acid receptor 1 (LPAR1; formerly known as EDG2, GPR26)
- Lysophosphatidic acid receptor 2 (LPAR2; formerly known as EDG4)
- Lysophosphatidic acid receptor 3 (LPAR3; formerly known as EDG7)
- Lysophosphatidic acid receptor 4 (LPAR4; formerly known as GPR23, P2RY9)
- Lysophosphatidic acid receptor 5 (LPAR5; formerly known as GPR92)
- Lysophosphatidic acid receptor 6 (LPAR6; formerly known as GPR87, P2RY5)
See also
- Lysophospholipid receptor
- Sphingosine-1-phosphate receptor
- P2Y receptor
References
Membrane proteins, receptors: cell surface receptors |
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| G protein-coupled receptor | | Class A | |
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| Class B | |
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| Class C |
- Metabotropic glutamate receptor
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| Class D | |
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| Class E | |
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| Class F | |
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| Ligand-gated ion channel | |
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| Enzyme-linked receptor |
- Serine/threonine-specific protein kinase
- Receptor tyrosine kinase
- Guanylate cyclase
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| Other/ungrouped |
- Asialoglycoprotein receptor
- Tumor necrosis factor receptor
- Immunoglobulin superfamily
- N-Acetylglucosamine receptor
- Neuropilins
- Transferrin receptor
- EDAR
- Lipoprotein receptor-related protein
- Progestin and adipoQ receptor
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Cell surface receptor: G protein-coupled receptors |
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Class B: Secretin-like |
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| Adhesion |
- ADGRB
- Brain-specific angiogenesis inhibitor
- ADGRC
- ADGRE
- ADGRG
- ADGRL
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| Orphan |
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
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| Other |
- Calcitonin
- CALCRL
- Corticotropin-releasing hormone (1
- 2)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth-hormone-releasing hormone
- PACAPR1
- GPR
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
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| Taste, sweet |
- TAS1R
- Vomeronasal receptor, type 2
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| Other |
- Calcium-sensing receptor
- GABAB (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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Class F: Frizzled & Smoothened |
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| Frizzled |
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
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| Smoothened | |
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| Extracellular | | Eicosanoids | |
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| Lysophospholipids | |
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| Steroids | |
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| Others | |
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| Intracellular | | Nuclear receptor | |
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| Second messenger |
- General: Arachidonic acid
- DAG (PKC, TRPC)
- IP3 (IP3R, RyR)
- Phosphatidic acid
- Phosphoinositides: PIP2 (IRKs)
- PIP3 (PKB/Akt, Btk, PDPK1)
- PtdIns(3,4)P2 (PKB/Akt, PDPK1); Sphingolipids: C1P
- Ceramide (CAPPs, KSR1, PKCζ, CTSD)
- Glucosylceramides
- S1P
- Sphingosine (SDK1, PKH, YPK)
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| Precursors | |
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Receptor (ligands) | | Tooltip Lysophosphatidic acid receptor |
- Agonists: 1-Oleoyl-LPA
- 1-Palmitoyl-LPA
- GRI-977143
- LPA
- OMPT
- Antagonists: H2L-5186303
- H2L-5765834
- Ki-16425
- TC-LPA5 4
- VPC-32183
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| S1PRTooltip Sphingosine-1-phosphate receptor |
- Agonists: Amiselimod
- Cenerimod
- Ceralifimod
- CS-2100
- CYM-5442
- CYM-5520
- CYM 5541
- CYM-50260
- CYM-50308
- Dihydro-S1P (sphinganine 1-phosphate)
- Fingolimod
- Fingolimod phosphate
- KRP-203
- Mocravimod
- Ozanimod
- Phyto-S1P
- Ponesimod
- RP-001
- RP-002
- RPC-1063
- SEW-2871
- Siponimod
- S1P
- SPC
- TC-G 1006
- TC-SP 14
- W-061
- XAX-162
- Antagonists: CS-0777
- CYM-50358
- JTE-013
- TY-52156
- VPC-23019
- W-146
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Enzyme (inhibitors) | | SPTTooltip Serine C-palmitoyltransferase | |
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| Ceramidase | |
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| SphKTooltip Sphingosine kinase | |
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| Others |
- Precursors: LPA: LPC; S1P: Palmitoyl-CoA
- Serine
- 3-Ketosphinganine (dehydrosphingosine)
- Dihydrosphingosine (sphinganine)
- Dihydroceramide
- Ceramide
- Sphingosine
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See also: Receptor/signaling modulators |