A steroid hydroxylase is a class of hydroxylase enzymes involved in the biosynthesis of steroids.[1][2]
See also
Additional images
References
- ^ Waterman, M. R.; Simpson, E. R. (2022-02-07), Chapter 3. Mechanisms of Regulation of Steroid Hydroxylase Gene Expression, De Gruyter, pp. 101–152, doi:10.1515/9783112563281-004, ISBN 978-3-11-256328-1, retrieved 2023-03-17
- ^ Waterman, MICHAEL R.; Simpson, EVAN R. (1989-01-01), Clark, JAMES H. (ed.), "Regulation of Steroid Hydroxylase Gene Expression Is Multifactorial in Nature", Proceedings of the 1988 Laurentian Hormone Conference, Recent Progress in Hormone Research, vol. 45, Boston: Academic Press, pp. 533–566, doi:10.1016/b978-0-12-571145-6.50016-9, ISBN 978-0-12-571145-6, PMID 2554434, retrieved 2023-03-17
External links
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| Mevalonate pathway | | To HMG-CoA |
- Acetyl-Coenzyme A acetyltransferase
- HMG-CoA synthase (regulated step)
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| Ketogenesis |
- HMG-CoA lyase
- 3-hydroxybutyrate dehydrogenase
- Thiophorase
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| To Mevalonic acid | |
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| To DMAPP |
- Mevalonate kinase
- Phosphomevalonate kinase
- Pyrophosphomevalonate decarboxylase
- Isopentenyl-diphosphate delta isomerase
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| Geranyl- |
- Dimethylallyltranstransferase
- Geranyl pyrophosphate
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| To cholesterol | | To lanosterol |
- Farnesyl-diphosphate farnesyltransferase
- Squalene monooxygenase
- Lanosterol synthase
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| 7-Dehydrocholesterol path |
- Lanosterol 14α-demethylase
- Sterol-C5-desaturase-like
- 7-Dehydrocholesterol reductase
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| Desmosterol path |
- 24-Dehydrocholesterol reductase
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| To Bile acids | |
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| Steroidogenesis | |
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| 1.14.11: 2-oxoglutarate |
- Prolyl hydroxylase
- HIF prolyl-hydroxylase
- P4HTM
- Lysyl hydroxylase
- AlkB
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| 1.14.13: NADH or NADPH | |
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| 1.14.14: reduced flavin or flavoprotein | |
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| 1.14.15: reduced iron–sulfur protein | |
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| 1.14.16: reduced pteridine (BH4 dependent) | |
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| 1.14.17: reduced ascorbate | |
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| 1.14.18-19: other |
- Tyrosinase
- Stearoyl-CoA desaturase-1
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| 1.14.99 - miscellaneous | |
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Enzymes |
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Diffusion-limited enzyme
- Cofactor
- Enzyme catalysis
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| Regulation | |
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
- EC7 Translocases (list)
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