3'-Me-PCP |
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1-[1-(3-methylphenyl)cyclohexyl]piperidine
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| Formula | C18H27N |
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| Molar mass | 257.421 g·mol−1 |
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CC1=CC(=CC=C1)C2(CCCCC2)N3CCCCC3
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InChI=1S/C18H27N/c1-16-9-8-10-17(15-16)18(11-4-2-5-12-18)19-13-6-3-7-14-19/h8-10,15H,2-7,11-14H2,1H3 Key:BMFKUCGCXMDGBK-UHFFFAOYSA-N
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3-Methyl-PCP (3'-Methyl-PCP, meta-Methyl-PCP, 3-Me-PCP) is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative, related to drugs such as 3'-MeO-PCP and 3'-Me-PCPy.[1][2] It was first synthesised in the 1960s,[3] but was only identified on the illicit market in Hungary in September 2020,[4] and was made illegal in Hungary in April 2021.[5]
See also
References
- ^ Linders J, Furlano DC, Mattson MV, Jacobson AE, Rice KC (February 2010). "Synthesis and preliminary biochemical evaluation of novel derivatives of PCP". Letters in Drug Design & Discovery. 7 (2): 79–87. doi:10.2174/157018010790225813.
- ^ Wallach J, De Paoli G, Adejare A, Brandt SD (2014). "Preparation and analytical characterization of 1-(1-phenylcyclohexyl)piperidine (PCP) and 1-(1-phenylcyclohexyl)pyrrolidine (PCPy) analogues". Drug Testing and Analysis. 6 (7–8): 633–50. doi:10.1002/dta.1468. PMID 23554350.
- ^ Maddox VH, Godefroi EF, Parcell RF (March 1965). "The synthesis of phencyclidine and other 1-arylcyclohexylamines". Journal of Medicinal Chemistry. 8 (2): 230–5. doi:10.1021/jm00326a019. PMID 14332667.
- ^ Jankovic M (28 January 2021). "EU Early Warning System" (PDF). Der Koordinator für Psychiatrie, Sucht- und Drogenfragen und der Beauftragte für Sucht- und Drogenfragen der Stadt Wien.
- ^ Minister for Human Capacities. "Amendment of Minister for Human Capacities Decree No 55/2014 of 30 December 2014 on substances or groups of compounds classified as new psychoactive substances, 2021/225/HU". European Commission.
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Dissociatives (NMDAR antagonists) | |
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Deliriants (mAChR antagonists) | |
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Cannabinoids (CB1R agonists) | |
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Inhalants (mixed MoATooltip mechanism of action) |
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| Others |
- Aminochromes (e.g., adrenochrome, adrenolutin)
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| AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor | |
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| KARTooltip Kainate receptor | |
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| NMDARTooltip N-Methyl-D-aspartate receptor | |
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- See also: Receptor/signaling modulators
- Metabotropic glutamate receptor modulators
- Glutamate metabolism/transport modulators
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| Group I | | mGluR1Tooltip Metabotropic glutamate receptor 1 | |
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| mGluR5Tooltip Metabotropic glutamate receptor 5 | |
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| Group II | | mGluR2Tooltip Metabotropic glutamate receptor 2 | |
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| mGluR3Tooltip Metabotropic glutamate receptor 3 | |
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| Group III | | mGluR4Tooltip Metabotropic glutamate receptor 4 |
- Antagonists: CPPG
- MAP4
- MPPG
- MSOP
- MTPG
- UBP-1112
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| mGluR6Tooltip Metabotropic glutamate receptor 6 |
- Antagonists: CPPG
- MAP4
- MPPG
- MSOP
- MTPG
- UBP-1112
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| mGluR7Tooltip Metabotropic glutamate receptor 7 |
- Antagonists: CPPG
- MAP4
- MMPIP
- MPPG
- MSOP
- MTPG
- UBP-1112
- XAP044; Negative allosteric modulators: ADX71743
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| mGluR8Tooltip Metabotropic glutamate receptor 8 |
- Antagonists: CPPG
- MAP4
- MPPG
- MSOP
- MTPG
- UBP-1112
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators |
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| σ1 | |
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| Unsorted |
- Antagonists: AHD1
- AZ66
- Lamotrigine
- Naloxone
- SM-21
- UMB-100
- UMB-101
- UMB-103
- UMB-116
- YZ-011
- YZ-069
- YZ-185
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See also: Receptor/signaling modulators |