FUB-144

FUB-144
Legal status
Legal status	CA: Schedule II; DE: NpSG (Industrial and scientific use only); UK: Class B; US: Schedule I;
Identifiers
	IUPAC name [1-(4-Fluorobenzyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone;
CAS Number	2185863-15-2 ;
PubChem CID	118796439;
ChemSpider	30646792;
UNII	IWY4W66OKW;
CompTox Dashboard (EPA)	DTXSID201016907 ;
Chemical and physical data
Formula	C23H24FNO
Molar mass	349.449 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccc(cc1)Cn1cc(c2c1cccc2)C(=O)C1C(C1(C)C)(C)C;
	InChI InChI=1S/C23H24FNO/c1-22(2)21(23(22,3)4)20(26)18-14-25(19-8-6-5-7-17(18)19)13-15-9-11-16(24)12-10-15/h5-12,14,21H,13H2,1-4H3; Key:UXOFEILQVZFLRH-UHFFFAOYSA-N;

FUB-144 (also known as FUB-UR-144) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor^[1] and has been sold online as a designer drug.^[2] It is an analogue of UR-144 and XLR-11 where the pentyl chain has been replaced with fluorobenzyl.

Legal status

In the United States, FUB-144 was temporarily emergency scheduled by the DEA in 2019.^[3] and made a permanent Schedule I Controlled Substance on April 7, 2022.^[4]

Sweden's public health agency suggested classifying FUB-144 as hazardous substance on March 24, 2015.^[5]

References

^ Marusich JA, Gamage TF, Zhang Y, Akinfiresoye LR, Wiley JL (October 2022). "In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonists". Pharmacology, Biochemistry, and Behavior. 220: 173467. doi:10.1016/j.pbb.2022.173467. PMC 9837865. PMID 36154844.
^ "FUB-144". Southern Association of Forensic Scientists. Archived from the original on 27 September 2015. Retrieved 23 July 2015.
^ "Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I". Federal Register.
^ "Schedules of Controlled Substances: Placement of 5F-EDMB-PINACA, 5FMDMB-PICA, FUB-AKB48, 5F-CUMYLPINACA, and FUB-144 in Schedule I" (PDF). Federal Register. 87 (67). 7 April 2022.
^ "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara". Folkhälsomyndigheten. Retrieved 23 July 2015.

[Marusich_2022-1] Marusich JA, Gamage TF, Zhang Y, Akinfiresoye LR, Wiley JL (October 2022). "In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonists". Pharmacology, Biochemistry, and Behavior. 220: 173467. doi:10.1016/j.pbb.2022.173467. PMC 9837865. PMID 36154844.

[2] "FUB-144". Southern Association of Forensic Scientists. Archived from the original on 27 September 2015. Retrieved 23 July 2015.

[fedreg-Apr-2019-3] "Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I". Federal Register.

[4] "Schedules of Controlled Substances: Placement of 5F-EDMB-PINACA, 5FMDMB-PICA, FUB-AKB48, 5F-CUMYLPINACA, and FUB-144 in Schedule I" (PDF). Federal Register. 87 (67). 7 April 2022.

[5] "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara". Folkhälsomyndigheten. Retrieved 23 July 2015.

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Legal status

See also

References