Prazitone

Prazitone
Clinical data
Other namesAGN-511; 5-Phenyl-5-(2-piperidylmethyl)barbituric acid
ATC code
  • none
Identifiers
IUPAC name
  • 5-phenyl-5-(piperidin-2-ylmethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H19N3O3
Molar mass301.346 g·mol−1
3D model (JSmol)
SMILES
  • C1CCNC(C1)CC2(C(=O)NC(=O)NC2=O)C3=CC=CC=C3
InChI
  • InChI=1S/C16H19N3O3/c20-13-16(11-6-2-1-3-7-11,14(21)19-15(22)18-13)10-12-8-4-5-9-17-12/h1-3,6-7,12,17H,4-5,8-10H2,(H2,18,19,20,21,22) N
  • Key:UGZAKKMLMJITLL-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

Prazitone (INNTooltip International Nonproprietary Name, BANTooltip British Approved Name; developmental code name AGN-511) is a barbiturate derivative described as an antidepressant which was developed in the 1960s.[1][2] Unlike most barbiturates, it has little or no sedative effects, instead acting as a non-sedating anxiolytic and antidepressant.[3][1] The dosage range in humans is around 200–600 mg, although higher doses have been used in trials for the treatment of depression associated with Parkinson's disease.

References

  1. ^ a b Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1011. ISBN 978-1-4757-2085-3. Retrieved 20 October 2024.
  2. ^ DE 1645911, Wiggins LF, Gittos MW, James JW, "Process for the preparation of derivatives of barbituric acid", issued 30 May 1973, assigned to Aspro Nicholas Ltd. 
  3. ^ US 3806596, Langlands R, "Method for imparting anti-depressant and/or anxiolytic effects to animals.", issued 23 March 1974, assigned to Aspro Nicholas Ltd. 


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