Safrazine |
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| Other names | 4-benzo[1,3]dioxol-5-ylbutan-2-ylhydrazine; [3-(3,4-(methylenedioxy)phenyl)-1-butyl]hydrazine; 2-piperonylisopropylhydrazine |
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Routes of administration | Oral |
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| Legal status |
- In general: ℞ (Prescription only)
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[3-(1,3-benzodioxol-5-yl)-1-methyl-propyl]hydrazine
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| Formula | C11H16N2O2 |
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| Molar mass | 208.261 g·mol−1 |
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Safrazine (Safra) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was introduced as an antidepressant in the 1960s, but has since been discontinued alongside several old generation MAOIs in favor of the invention of RIMAs and more efficacious treatments for depression in general. [1]
See also
References
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| SSRIsTooltip Selective serotonin reuptake inhibitors | |
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| SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors | |
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| NRIsTooltip Norepinephrine reuptake inhibitors | |
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| NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors | |
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| NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants | |
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| SARIsTooltip Serotonin antagonist and reuptake inhibitors | |
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| SMSTooltip Serotonin modulator and stimulators | |
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| Others | |
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| TCAsTooltip Tricyclic antidepressants | |
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| TeCAsTooltip Tetracyclic antidepressants | |
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| Others | |
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| Non-selective | |
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| MAOATooltip Monoamine oxidase A-selective | |
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| MAOBTooltip Monoamine oxidase B-selective | |
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| Non-specific | | AAADTooltip Aromatic L-amino acid decarboxylase | |
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| MAOTooltip Monoamine oxidase | |
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Phenethylamines (dopamine, epinephrine, norepinephrine) | | PAHTooltip Phenylalanine hydroxylase |
- Substrates→Products: Phenylalanine→Tyrosine
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| THTooltip Tyrosine hydroxylase | |
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| DBHTooltip Dopamine beta-hydroxylase | |
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| PNMTTooltip Phenylethanolamine N-methyltransferase |
- Inhibitors: CGS-19281A
- SKF-64139
- SKF-7698
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| COMTTooltip Catechol-O-methyl transferase | |
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Tryptamines (serotonin, melatonin) | | TPHTooltip Tryptophan hydroxylase |
- Substrates→Products: Tryptophan→5-HTP
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| AANATTooltip Serotonin N-acetyl transferase | |
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| ASMTTooltip Acetylserotonin O-methyltransferase | |
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| Histamine | | HDCTooltip Histidine decarboxylase |
- Substrates→Products: L-Histidine→Histamine
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| HNMTTooltip Histamine N-methyltransferase |
- Substrates→Products: Histamine→N-Methylhistamine
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| DAOTooltip Diamine oxidase |
- Substrates→Products: Histamine→Imidazole acetic acid
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See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins |