Bone morphogenetic protein receptor

TKL Ser/Thr protein kinase family
Identifiers
SymbolTKL
Membranome1216

Bone morphogenetic protein receptors are serine-threonine kinase receptors. Transforming growth factor beta family proteins bind to these receptors.[1] There are four bone morphogenetic protein receptors:[2]

  • Bone morphogenetic protein receptor, type 1:
    • ACVR1
    • BMPR1A
    • BMPR1B
  • Bone morphogenetic protein receptor, type 2

Structure

Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain.[3] Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade.[3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.[4]

See also

  • Bone morphogenetic protein

References

  1. ^ Miyazono K, Kamiya Y, Morikawa M (January 2010). "Bone morphogenetic protein receptors and signal transduction". Journal of Biochemistry. 147 (1): 35–51. doi:10.1093/jb/mvp148. PMID 19762341.
  2. ^ Pasche B (December 2008). "The TGF Family. Cold Spring Harbor Monograph Series, Volume 50. Edited by Rik Derynck, Kohei Miyazono. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. xiv-1114 p.; ill.; index. 9780879697525. 2008". The Quarterly Review of Biology. 83 (4): 405–405. doi:10.1086/596254.
  3. ^ a b Mace PD, Cutfield JF, Cutfield SM (December 2006). "High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding". Biochemical and Biophysical Research Communications. 351 (4): 831–8. doi:10.1016/j.bbrc.2006.10.109. PMID 17094948.
  4. ^ Miyazono K, Shimanuki T (January 2008). "Chapter 55: Bone morphogenetic protein receptors and actions.". In Bilezikian JP, Raisz LG, Martin TJ (eds.). Principles of bone biology (Third ed.). San Diego: Academic Press. pp. 1177–1196. doi:10.1016/B978-0-12-373884-4.00069-0. ISBN 978-0-12-373884-4.
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