Isothipendyl

Isothipendyl
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • N,N-dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propan-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.006.890
Chemical and physical data
FormulaC16H19N3S
Molar mass285.41 g·mol−1
3D model (JSmol)
SMILES
  • n2c1N(c3c(Sc1ccc2)cccc3)CC(N(C)C)C
InChI
  • InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3 Y
  • Key:OQJBSDFFQWMKBQ-UHFFFAOYSA-N Y
  (verify)

Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.[1] In the 2020s, at least, it is rarely used in the first line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).

See also

References

  1. ^ Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, et al. (2012). "Contact photoallergy to isothipendyl chlorhydrate". Dermatology. 224 (4): 289–291. doi:10.1159/000338024. PMID 22677929. S2CID 27580642.
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