Methimepip
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| Names
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| IUPAC name
4-(1H-imidazol-4-ylmethyl)-1-methylpiperidine
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| Identifiers
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CAS Number
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3D model (JSmol)
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| ChEMBL
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| MeSH
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C500075
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| UNII
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InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12) N Key: KIAVPENCSGKVQP-UHFFFAOYSA-N N InChI=1/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12) Key: KIAVPENCSGKVQP-UHFFFAOYAQ
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| Properties
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Chemical formula
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C10H17N3
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| Molar mass
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179.262 g/mol
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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Methimepip is a histamine agonist which is highly selective for the H3 subtype. It is the N-methyl derivative of immepip.[1]
References
- ^ Kitbunnadaj R, Hashimoto T, Poli E, et al. (March 2005). "N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist". Journal of Medicinal Chemistry. 48 (6): 2100–7. doi:10.1021/jm049475h. PMID 15771452.
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| H1 | | Agonists | |
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| Antagonists |
- Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, brilaroxazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine)
- Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)
- Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline)
- Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine)
- Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene)
- Unknown/unsorted: Azanator
- Belarizine
- Elbanizine
- Flotrenizine
- GSK1004723
- Napactadine
- Tagorizine
- Trelnarizine
- Trenizine
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| H2 | |
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| H3 | |
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| H4 | | Agonists |
- 4-Methylhistamine
- α-Methylhistamine
- Histamine
- L-Histidine
- OUP-16
- VUF-8430
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- See also
- Receptor/signaling modulators
- Monoamine metabolism modulators
- Monoamine reuptake inhibitors
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