THCP-O-acetate

THCP-O-acetate
Identifiers
	IUPAC name (6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl acetate;
CAS Number	2829292-82-0;
ChemSpider	129341098;
Chemical and physical data
Formula	C25H36O3
Molar mass	384.560 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)Oc1cc(CCCCCCC)cc2OC(C)(C)[C@@H]3CCC(C)=C[C@H]3c21;
	InChI InChI=1S/C25H36O3/c1-6-7-8-9-10-11-19-15-22(27-18(3)26)24-20-14-17(2)12-13-21(20)25(4,5)28-23(24)16-19/h14-16,20-21H,6-13H2,1-5H3/t20-,21-/m1/s1; Key:OXMUZNKOOOITQD-NHCUHLMSSA-N;

THCP-O-acetate (THCP-O) is a semi-synthetic derivative of tetrahydrocannabiphorol (THCP) derived by acetylation of the OH group. It has been found as a component of grey-market cannabis products such as e-cigarette liquids and edible gummy lollies, and is allegedly a potent and long-lasting psychoactive cannabinoid.^[1]

Toxicity

In 2022, researchers at Portland State University who screened for the presence of reacted ketene as N-benzylacetamide reported that Vitamin E acetate, CBD-acetate, CBN-acetate and THC-O-acetate may break down to release ketene gas when heated at 340 °C (644 °F).^[2]^[3]

Legality

Japan banned THCP-O-Acetate along with HHCP on December 26, 2023.^[4]

References

^ Erickson BE (2023). "Waiting for CBD regulations in the US". Chemical & Engineering News. 101 (28): 17–19. doi:10.1021/cen-10128-feature1. S2CID 261318144.
^ Munger KR, Jensen RP, Strongin RM (July 2022). "Vaping Cannabinoid Acetates Leads to Ketene Formation". Chemical Research in Toxicology. 35 (7): 1202–1205. doi:10.1021/acs.chemrestox.2c00170. PMID 35801872.
^ Sagen J, Paikoff S, Ford J, Newman D, Jyot J (2022). "Proceedings of the 2022 Cannabis Clinical Outcomes Research Conference (CCORC) Orlando, FL, USA, May 19-20, 2022". Medical Cannabis and Cannabinoids. 5 (1): 142–158. doi:10.1159/000527081. PMC 9729860.
^ "Japan bans sale of 38 goods with synthetic cannabis compounds". The Japan Times. 22 December 2023.

[1] Erickson BE (2023). "Waiting for CBD regulations in the US". Chemical & Engineering News. 101 (28): 17–19. doi:10.1021/cen-10128-feature1. S2CID 261318144.

[2] Munger KR, Jensen RP, Strongin RM (July 2022). "Vaping Cannabinoid Acetates Leads to Ketene Formation". Chemical Research in Toxicology. 35 (7): 1202–1205. doi:10.1021/acs.chemrestox.2c00170. PMID 35801872.

[3] Sagen J, Paikoff S, Ford J, Newman D, Jyot J (2022). "Proceedings of the 2022 Cannabis Clinical Outcomes Research Conference (CCORC) Orlando, FL, USA, May 19-20, 2022". Medical Cannabis and Cannabinoids. 5 (1): 142–158. doi:10.1159/000527081. PMC 9729860.

[4] "Japan bans sale of 38 goods with synthetic cannabis compounds". The Japan Times. 22 December 2023.

[1]

[2]

[3]

[4]

Toxicity

Legality

See also

References