Cannabigerolic acid

Cannabigerolic acid
Names
	Preferred IUPAC name 3-[(2E)-3,7-Dimethylocta-2,6-dien-1-yl]-2,4-dihydroxy-6-pentylbenzoic acid
Identifiers
CAS Number	25555-57-1;
ChEBI	CHEBI:67081;
ChEMBL	ChEMBL463843;
ChemSpider	4952655;
KEGG	C20406;
PubChem CID	6449999;
UNII	80I4ZM847Y;
CompTox Dashboard (EPA)	DTXSID401315426 ;
Properties
Chemical formula	C22H32O4
Molar mass	360.494 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Cannabigerolic acid (CBGA) is the acidic form of cannabigerol (CBG). It is a dihydroxybenzoic acid and olivetolic acid in which the hydrogen at position 3 is substituted by a geranyl group. It is a biosynthetic precursor to Delta-9-tetrahydrocannabinol, which is the principal psychoactive constituent of the Cannabis plant. It is also a meroterpenoid (i.e. a polyketide and a terpenoid), a member of resorcinols and a phytocannabinoid. It derives from an olivetolic acid. It is a conjugate acid of a cannabigerolate.^[1]

In the Cannabis plant, olivetolic acid and geranyl diphosphate are synthesized into CBGA.^[2]^: 6^[3]^: 17 CBGA is converted in the plant by CBCA synthase, CBDA synthase and THCA synthase into CBCA, CBDA and THCA respectively.^[2]^: 6–7

References

^ "Cannabigerolic acid". PubChem. United States National Library of Medicine. Retrieved April 7, 2020.
^ ^a ^b Thomas BF, ElSohly MA (2015). The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations. Emerging Issues in Analytical Chemistry. Elsevier Science. ISBN 978-0-12-804670-8.
^ Degenhardt VF, Stehle F, Kayser O (2016). "The biosynthesis of cannabinoids". In Preedy VR (ed.). Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Academic Press. pp. 13–23. ISBN 978-0128008270.

This article incorporates public domain material from websites or documents of the National Institutes of Health.

[1] "Cannabigerolic acid". PubChem. United States National Library of Medicine. Retrieved April 7, 2020.

[Thomas_2015-2] Thomas BF, ElSohly MA (2015). The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations. Emerging Issues in Analytical Chemistry. Elsevier Science. ISBN 978-0-12-804670-8.

[Degenhardt_2016-3] Degenhardt VF, Stehle F, Kayser O (2016). "The biosynthesis of cannabinoids". In Preedy VR (ed.). Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Academic Press. pp. 13–23. ISBN 978-0128008270.

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