GSK1702934A

GSK1702934A
Identifiers
	IUPAC name 3-[1-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one;
CAS Number	924377-85-5;
PubChem CID	16376051;
ChemSpider	10981314;
CompTox Dashboard (EPA)	DTXSID701336582 ;
Chemical and physical data
Formula	C22H25N3O2S
Molar mass	395.52 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCC2=C(CC1)SC(=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5NC4=O;
	InChI InChI=1S/C22H25N3O2S/c26-21(20-14-15-6-2-1-3-9-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(18)23-22(25)27/h4-5,7-8,14,16H,1-3,6,9-13H2,(H,23,27); Key:AXWRAIIIBRLXBP-UHFFFAOYSA-N;

GSK1702934A is a chemical compound which acts as an activator of the TRPC family of calcium channels, with selectivity for the TRPC3 and TRPC6 subtypes. It has been used to investigate the role of TRPC channels in heart function and regulation of blood pressure, as well as roles in the brain.^[1]^[2]^[3]^[4]

References

^ Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg (2013). "CG Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists". Biophysical Journal. 104 (2): 454a. Bibcode:2013BpJ...104..454X. doi:10.1016/j.bpj.2012.11.2513.
^ Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K (April 2015). "TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1". Cardiovascular Research. 106 (1): 163–73. doi:10.1093/cvr/cvv022. PMC 4362401. PMID 25631581.
^ Tiapko O, Groschner K (July 2018). "TRPC3 as a Target of Novel Therapeutic Interventions". Cells. 7 (7): 83. doi:10.3390/cells7070083. PMC 6071100. PMID 30037143.
^ Wang Y, Liu L, Tao H, Wen L, Qin S (December 2020). "TRPC6 participates in the development of blood pressure variability increase in sino-aortic denervated rats". Heart and Vessels. 35 (12): 1755–1765. doi:10.1007/s00380-020-01682-1. PMID 32844288. S2CID 221309937.

[1] Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg (2013). "CG Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists". Biophysical Journal. 104 (2): 454a. Bibcode:2013BpJ...104..454X. doi:10.1016/j.bpj.2012.11.2513.

[pmid25631581-2] Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K (April 2015). "TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1". Cardiovascular Research. 106 (1): 163–73. doi:10.1093/cvr/cvv022. PMC 4362401. PMID 25631581.

[pmid30037143-3] Tiapko O, Groschner K (July 2018). "TRPC3 as a Target of Novel Therapeutic Interventions". Cells. 7 (7): 83. doi:10.3390/cells7070083. PMC 6071100. PMID 30037143.

[pmid32844288-4] Wang Y, Liu L, Tao H, Wen L, Qin S (December 2020). "TRPC6 participates in the development of blood pressure variability increase in sino-aortic denervated rats". Heart and Vessels. 35 (12): 1755–1765. doi:10.1007/s00380-020-01682-1. PMID 32844288. S2CID 221309937.

[1]

[2]

[3]

[4]